Miconazole 7 Combination Pack

Miconazole 7 Combination Pack - General Information

An imidazole antifungal agent that is used topically and by intravenous infusion. [PubChem]

Pharmacology of Miconazole 7 Combination Pack

Miconazole 7 Combination Pack is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the vagina for fungal infections. Miconazole 7 Combination Pack was approved by the FDA in 1974. Miconazole 7 Combination Pack prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.

Miconazole 7 Combination Pack for patients

Miconazole 7 Combination Pack Interactions

Miconazole 7 Combination Pack Contraindications

When used by a person taking the anticoagulant medication warfarin, Miconazole may cause an adverse reaction which can lead to excessive bleeding or bruising.

Additional information about Miconazole 7 Combination Pack

Miconazole 7 Combination Pack Indication: For topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor.
Mechanism Of Action: Miconazole 7 Combination Pack interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole 7 Combination Pack may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Drug Interactions: Warfarin Vaginal miconazole increases the anticoagulant effect
Acenocoumarol Vaginal miconazole increases the anticoagulant effect
Dicumarol Vaginal miconazole increases the anticoagulant effect
Anisindione Vaginal miconazole increases the anticoagulant effect
Food Interactions: Not Available
Generic Name: Miconazole
Synonyms: MCZ
Drug Category: Antifungal Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Miconazole: Daktarin; Femizol-M; M-zole 3 Combination Pack; M-zole 7 Dual Pack; Micatin; Miconazole 3; Miconazole 3 Combination Pack; Miconazole 7; Miconazole 7 Combination Pack; Miconazole Nitrate; Miconazole Nitrate Combination Pack; Miconazole-7; Micozole; Minostate; Monazole 7; Monistat; Monistat 1 Combination Pack; Monistat 3; Monistat 3 Combination Pack; Monistat 3 Dual-Pak; Monistat 3 Vaginal Ovules; Monistat 5; Monistat 5 Tampon; Monistat 7; Monistat 7 Combination Pack; Monistat 7 Dual-Pak; Monistat 7 Vaginal Suppositories; Monistat Dual- PAK; Monistat IV; Monistat-3 Combination Pack; Monistat-Derm; Novo-Miconazole Vaginal Ovules;
Absorption: Not Available
Toxicity (Overdose): Oral, mouse: LD₅₀ = 3800 mg/kg; Oral, rat: LD₅₀ = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Miconazole 7 Combination Pack: Aerosol Topical
Cream Topical
Suppository Intravaginal
Cream Intravaginal
Chemical IUPAC Name: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
Chemical Formula: C18H14Cl4N2O
Miconazole on Wikipedia: https://en.wikipedia.org/wiki/Miconazole
Organisms Affected: Fungi, yeast and protozoans